Dong Hoon Shin MD, PhD, MS. Lab of Bioanthropology, Paleopathology and History of Diseases, Department of Anatomy/Institute of Forensic Science, Seoul National University College of Medicine, 103 Daehak-ro (Yongon-dong), Jongno-gu, Seoul 03080, South Korea. E-mail: firstname.lastname@example.org(DH Shin); TEL: +82-2-740-8203; FAX: +82-2-745-9528
Invited Speaker: The 2017 Congress of the European Society for Evolutionary Biology
I am invited to
The 2017 Congress of the European Society for Evolutionary Biology
(20-25 August 2017 in Groningen, the Netherlands)
[S2] The spread and evolution of ancient infectious diseases
The Scientific Studies on Ancient Parasite Infection of East Asia by Microscopic and Genetic Researches
Dong Hoon Shin
Bioanthropology and Paleopathology Lab, Seoul National University College of Medicine, South Korea
Only about 100 years ago, parasite disease was one of the most prevalent diseases worldwide. The recent development of paleo-parasitology using archaeological samples can provide a wealth of information, making a scientific basis for understanding of ancient parasitism in history. Although East Asia is a region with a long history, the academic tradition of the research on the ancient parasitism was very weak. In recent years, however, interdisciplinary studies successfully revealed how the people of the area were affected by parasite infection in the past; and further analyzed even the ancient parasite genes. Actually, through the microscopic examinations of the mummy coprolites, we estimated the infection prevalence of each parasite spp. in pre-modern East Asia. More interestingly, using the ancient DNA (aDNA) analysis, we also got the genetic information of the ancient parasites prevalent in this area. To date, we sequenced Ascaris, Trichuris, Clonorchis, and Paragonimus aDNA; and by the analysis of the accumulated genetic information, we gained scientific evidences for understanding the genetic traits of ancient parasites in the historical East Asia. By the approaches, we know how the pre-modern parasitism in here differs from now and how their genetic characteristics have changed over the years.
My lab performed excavation in Rakhigarhi/India for Feb 19 to Mar 8 (Hong JH); Mar 4 to Mar 13 (Shin DH), 2016. The excavation is supported by National Geographic Foundation.
The Camp site in Rakhigarhi
About the project this time for Rakhigarhi is as follows:
1. For many anthropologists worldwide, nothing is more important than the inhabitants of the Harappan (Indus Valley) civilization. In fact, there have been a number of spirited debates on the IVC. Some have contended that it might have been part of Harappan society, while others have disputed that. In previous investigations, researchers were unable to draw any definitive conclusions on the question of the in situ continuity of the Harappan people’s biological traits. Meanwhile, the health and disease status of the Harrapan people also has long attracted anthropologists’ interest. For the time being, the Harappan people, in their biological and anthropological aspects, remain shrouded in mystery.
2. The Rakhigarhi site, the…
"Partnering with the Archaeological Survey of India (ASI) and paleoparasitologists from the Seoul National University College of Medicine, Korea, scientists from the Deccan College Post-graduate and Research Institute will now try to capture and study the parasite eggs that once existed in the stomachs of those buried during the Harappan era, and ultimately isolate the DNA of their host,...." "This exercise is part of the fresh excavations that will start in Rakhigarhi from January 12 under the direction of Vasant Shinde, senior archaeologist and vice chancellor/director at the Deccan College Postgraduate and Research Institute. Some of these archaeologists have already reached ground zero and will begin excavation at 'mound number 4'-- the biggest and the tallest of the seven mounds here......." "The team of Korean scientists will reach Rakhigarhi on January 25 to begin…
아래 학생 질문에 대한 답입니다. 조교선생님들이 한번 더 공식적으로 공지 할 것입니다.
문) 오늘 설명하셨던 sensory tract부분에 대해 신경생리학 부분과 충돌 된다고 생각하는 것이 있어 질문올립니다!
Spinothalamic pathway: pain, temperature, light touch, pressure
Medial lemniscus system: discrimitive tactile sensation, vibration
각각의 tract가 담당하는 감각의 종류를 오늘의 강의에서는 위와 같이 분류해 놓았는데 신경생리학 체성감각 파트에서는 touch와 pressure에 대한 분류가 다르게 되어있어 혼동이 되었습니다.
신경생리학 강의에서의 분류는 다음과 같습니다.
Dorsal column-medial lemniscal pathway: '촉각', '압각', 진동감각, 고유감각, 두점식별
Spinothalamic pathway: 통각, 온각, 냉각
Brown-squard syndrome과 같이 infarction이 왔을 때 두 가지 감각의 분류가 어디로 들어가냐에 따라서 영향을 받는 곳에 대한 답이 다르게 나올 수 있다고 생각하여 통일하는 과정이 필요하다고 생각하였습니다.
답) 타당한 질문이며 생리학 교실 강의 내용을 함께 검토하여 우리 강의에서도 spinothalamic tract와 medial lemniscus system의 기능에 대해서는 아래 생리학 교실 강의에서 다룬 내용에 맞추어 통일 하도록 하겠습니다. 아래 슬라이드는 생리학 강의에서 이미 보셨지요? 기능에 대해서는 이에 준하여 이해해 주시기를 부탁합니다.